- Each tablet contains: 100 mg Sildenafil
- Validity: up to 4 hours
- Action starts: after 30- 40 minutes
- Active substance: Sildenafil (Citrate)
- Manufacturer: India
- Flavor: Bitter
Sildenafil Citrate treatment – the most popular and the most effective drugs to increase potency in the world. Generic Viagra provides a powerful blood flow and prevents its outflow, while erection occurs only if there is sexual arousal.
This medicine drug is not a hormonal remedy, arousal or aphrodisiac, which allows most patients to take Viagra daily. Buy Sildenafil with the delivery can be in our online pharmacy.
Method of application:
The action of Viagra begins 30 minutes after the intake and lasts a minimum of 4 hours.
Different patient groups and pharmacokinetics
Of the people who took the study, there were people over 65 years of age. Their condition was healthy. After all, it was found that people received a positive effect. After sildenafil, the clearance began to decrease. If you compare the result with young people, then in older people the concentration of the drug that was in the blood plasma increased, namely by 40%. In general, no side effects were observed from the action of the drug.
People who have impaired renal function
If a person has moderate or mild renal dysfunction, then there is nothing to worry about. It was proved that people with such diagnoses can drink once a drug, the dose of which will be 50 mg, and changes in the body will not be observed. Special studies were carried out which revealed this. The clearance of the drug can be reduced if it is taken by a person from a severe form of pathology. Immediately all the indicators will rise almost twice, if compared with healthy people.
People who have liver problems
Sildenafil’s clearance will decrease if a person has liver problems, namely cirrhosis of stage A and B. All indicators also increased compared to those seen in a healthy person of the same age. Studies have not been conducted for those people who have severe forms of liver pathology.
For an adult who has normal health, if he does not have any serious pathologies, the standard dose is 50 mg of the drug. Taking it costs an hour before sexual activity is planned, although its action can begin much earlier. The dose depends on how much the person can tolerate this drug, as well as on various other factors. It varies from 25 mg to 100 mg. But do not abuse the drug, it is recommended to do the reception no more than once a day.
People with impaired renal function:
If a person has a mild or moderate form of kidney pathology, the dose should be the same as that of a healthy person. You need to use much less drug (25 mg) to those who have severe kidney dysfunction, so as not to harm the body. This dose will be enough.
People with impaired liver function:
A person who has liver problems, it is best to use up to 25 mg of sildenafil. It depends on the fact that the drug is much heavier removed from the body in such people. Especially it concerns people with cirrhosis of the liver. But do not take this tool is not prohibited.
Combination with other means:
If a person takes ritonavir, the dose of sildenafil is limited. For two days you can use the drug only once, but do not forget about the dosage. The ideal index is 25 mg.
If a person takes a drug that belongs to inhibitors of the cytochrome isoenzyme CYP3A4, the dosage of sildenafil is reduced to 25 mg, or even less.
It is not recommended to take the drug to people who take a-address-blockers. After all, in aggregate, these funds can bring a hypotension. Later you can use sildenafil, but only when the level of hemodynamics is normalized. It is worth paying attention to the dose. Maybe in the beginning it needs to be done a little. It is worth taking care of your health.
To old people:
A person over 65 years of age does not need a specific dosage.
If you take the drug sildenafil in an amount of 800 mg, then the body will affect it negatively. After this, treatment may be required, which depends on the symptoms. The drug can not be excreted by the kidneys, since it is fixed by proteins.
Interaction with drugs:
Isozymes of cytochrome CYP3A4 and CYP2C9 affect the metabolism that passes through this drug. It follows that if a person takes any drugs, drugs that are considered inhibitors of these isoenzymes, then he must take into account the fact that they are able to reduce the clearance of sildenafil. From this it follows that inductor substances affect absolutely the opposite, they increase it. Multiple studies have shown that inhibitors of the cytochrome CYP3A4 isoenzyme only reduce the clearance of the drug. This includes ketonazole, erythromycin and others.